Assessing the Effectiveness of Oral Steroid Treatment in Patients of Nasal Polyposis, Scheduled forSurgery: AProspective Single-Arm Interventional Study: Oral Steroid in Nasal Polyposis

Saira Zaman; Athar Adnan Uppal; Ayesha Shahbaz; Hamza Yaseen; Tehrim Sabir

doi:10.70384/jlmdc.v3i01.98

Authors

Saira Zaman Department of Ear Nose Throat, Ghurki Trust Teaching Hospital, Lahore
Athar Adnan Uppal Department of Ear Nose Throat, Ghurki Trust Teaching Hospital, Lahore
Ayesha Shahbaz Department of Ear Nose Throat, Ghurki Trust Teaching Hospital, Lahore
Hamza Yaseen Department of Ear Nose Throat, Ghurki Trust Teaching Hospital, Lahore
Tehrim Sabir Department of Ear Nose Throat, Ghurki Trust Teaching Hospital, Lahore

DOI:

https://doi.org/10.70384/jlmdc.v3i01.98

Keywords:

Nasal polyps, Rhinosinusitis, SNOT22, Prednisolone

Abstract

Background: Nasal polyposis is a chronic inflammatory condition of the nasal mucosa characterized by benign polyps. Corticosteroids are the mainstay of treatment due to their anti-inflammatory effects, especially in patients awaiting surgery.

Objective: The objective of this study was to study the effectiveness of oral steroids by comparing the pre-medication and post-medication symptoms in patients of nasal polyposis scheduled for surgery.

Methodology: A prospective study was conducted in the ENT outpatient department of a tertiary care hospital after approval by the Institutional Review Board and included 196 patients diagnosed with nasal polyposis awaiting surgery. Participants received oral prednisolone at a dose of 1 mg/kg for 7–10 days with gradual tapering. Symptom severity and quality of life were assessed before and after the treatment using the Sino-Nasal Outcome Test-22 (SNOT-22). Statistical analysis was performed by SPSS version 26 to compare pre- and post-medication scores.

Results: Significant improvement was observed after treatment in nasal symptoms including congestion, sneezing, rhinorrhea, and postnasal discharge, as well as systemic and sleep-related complaints. The proportion of patients reporting moderate to severe nasal obstruction decreased markedly after treatment. The mean SNOT-22 score reduced from 63.71 ± 15.87 before treatment to 40.72 ± 9.20 after therapy, demonstrating a statistically significant improvement (p-value < 0.001).

Conclusion: Short-term oral steroid therapy effectively reduced symptom severity and improved quality of life in patients with nasal polyposis prior to surgery, supporting its use as an important preoperative management strategy.

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