Relation between Serum Uric Acid and Anthropometric Measures in Diabetic Nephropathy Patients

Abstract

Background: Diabetic nephropathy is a major challenge of diabetes mellitus, leading to significant morbidity
and mortality. Raised serum uric acid (SUA) tier is a potential cause of deterioration of kidney disease, such as
diabetic nephropathy.Anthropometric measuresfor instance Body MassIndex (BMI) and waist circumference
(WC) are crucial markers of adiposity, which is intimately linked to both progression of diabetic nephropathy
and hyperuricemia.

Objective: To evaluate the relation between SUAand anthropometric measures in diabetic nephropathy.
Methods: Across-sectional study was executed involving 150 patients by convenience sampling diagnosed
with diabetic nephropathy at the Diabetic Clinic of Tertiary care Hospital in Lahore. SUAlevels were measured
using enzymatic methods, while anthropometric measures, including BMI and waist circumference, were
recorded. The relation between SUA and these anthropometric measures was analyzed using Spearman correlation coefficient.

Results: The median (IQR) SUA in diabetic nephropathy patients was 6.9 (5.4-8.6) mg/dl and in healthy
group was 5.2 (4.6-6.2) mg/dl. In diabetic nephropathy group, a significant direct relation of SUAwas found
with BMI (rho = 0.296, p < 0.001) and also with waist circumference (rho = 0.435, p < 0.001). In healthy group,
significant directrelationwasfoundwithwaist circumference only (rho=0.212, p=0.001).SUA,Waist circumference and BMI were higher considerably in diabetic nephropathy when measured against the control.

Conclusion: The study demonstrates a significant relationship between elevated SUA levels and adverse
anthropometric measures in diabetic nephropathy patients. These findings suggest that managing obesity
through lifestyle modifications and pharmacotherapy could play a critical role in controlling SUA and
potentially slowing the progression of diabetic nephropathy.